Chronic Progressive Lymphedema - Equine Research Bank | Mad Barn USA (2024)

The Estimation of Genetic Parameters for Chronic Progressive Lymphedema and Body Traits in the Rhenish German Draught Horse.

Sievers J, Distl O.Chronic progressive lymphedema (CPL) is a prevalent and progressive disease in Rhenish German draught horses. The objective of our follow-up study was to evaluate the heritability of this disease in Rhenish German draught horses using pedigree-based and genomic relationship matrices. We employed linear and threshold animal models. Models included the random animal effect and effects of breeding association, coat colour, sex, and age within sex, and farm-related factors, on CPL scores. In addition, we estimated heritabilities in models assuming censoring for data when horses were below an age o...

Alleviating lesions of chronic progressive lymphedema in Belgian draft horses by successfully treating Chorioptes bovis infestation with moxidectin 0.5% pour-on.

Veterinary parasitology November 10, 2023 Volume 324110074doi: 10.1016/j.vetpar.2023.110074

Brys M, Claerebout E, Chiers K.The aim of this prospective, randomized, single-blinded, and placebo-controlled clinical trial was to investigate the efficacy of a moxidectin pour-on solution for the treatment of Chorioptes bovis infestation in Belgian draft horses, and in addition, to evaluate the effect of this treatment on the clinical signs and lesions associated with chronic progressive lymphedema (CPL). Nineteen privately owned Belgian draft horses were randomly assigned to either a treatment group (moxidectin pour-on formulation, n=10) or a placebo group (phosphate-buffered saline (PBS), n=9). On Day 0, all 19...

Chronic Progressive Lymphedema in Belgian Draft Horses: Understanding and Managing a Challenging Disease.

Veterinary sciences May 12, 2023 Volume 10, Issue 5347doi: 10.3390/vetsci10050347

Brys M, Claerebout E, Chiers K.Chronic progressive lymphedema (CPL) in draft horses is characterized by increased dermal thickness and fibrosis, with the development of skinfolds and nodules, hyperkeratosis, and ulcerations on the distal limbs of affected horses. Secondary bacterial, fungal, or parasitic infections frequently complicate and aggravate the lesions, as well as the progression of this disease. CPL has a particularly high prevalence of up to 85.86% in the Belgian draft horse breed. Due to the disease's progressive and incurable nature, affected horses are often euthanized prematurely. The treatment options are s...

Prevalence of Chronic Progressive Lymphedema in the Rhenish German Draught Horse.

Sievers J, Distl O.Chronic progressive lymphedema (CPL) is a common disease in Rhenisch German draught horses. The objective of our study was to evaluate the prevalence of this disease and its progression with age in 493 Rhenish German draught horses from different regions in Germany. We employed generalized linear models with binomial, multinomial, and normal distributions to analyse the effects of breeding association, coat colour, sex and age within sex, time of examination, limb on which CPL was recorded, and farm-related factors on disease scores. The occurrence and severity of CPL were significantly influe...

Assessment of plasma anti-elastin antibodies for use as a diagnostic aid for chronic progressive lymphoedema in Belgian Draught Horses.

De Keyser K, Berth M, Christensen N, Willaert S, Janssens S, Ducatelle R, Goddeeris BM, De co*ck HE, Buys N.Diagnosis of chronic progressive lymphoedema (CPL) in draught horses, including the Belgian Draught Horse, is mainly based on clinical evaluation of typical lower limb lesions. A deficient perilymphatic elastic support, caused by a pathological elastin degradation in skin and subcutis, has been suggested as a contributing factor for CPL. Elastin degradation products induce the generation of anti-elastin Ab (AEAb), detectable in horse serum by ELISA. For a clinically healthy group of draught horses, a significantly lower average AEAb-level than 3 clinically affected groups (mild, moderate and s...

Genetic parameters for chronic progressive lymphedema in Belgian Draught Horses.

De Keyser K, Janssens S, Peeters LM, Foquu00e9 N, Gasthuys F, Oosterlinck M, Buys N.Genetic parameters for chronic progressive lymphedema (CPL)-associated traits in Belgian Draught Horses were estimated, using a multitrait animal model. Clinical scores of CPL in the four limbs/horse (CPLclin ), skinfold thickness and hair samples (hair diameter) were studied. Due to CPLclin uncertainty in younger horses (progressive CPL character), a restricted data set (D_3+) was formed, excluding records from horses under 3years from the complete data set (D_full). Age, gender, coat colour and limb hair pigmentation were included as fixed, permanent environment and date of recording as ra...

What is your diagnosis? Chronic progressive lymphedema (CPL).

Boswell SG, Fogle CA, Linder K, Copple CN.No abstract available

Assessment of skinfold thickness as a factor related to chronic progressive lymphoedema in Belgian draught horses.

De Keyser K, Peeters LM, Buys N, Janssens S.No abstract available

Therapy for horses with chronic progressive lymphoedema.

Powell H.No abstract available

Quantitative and qualitative evaluation of dermal elastin of draught horses with chronic progressive lymphoedema.

De co*ck HE, Van Brantegem L, Affolter VK, Oosterlinck M, Ferraro GL, Ducatelle R.Chronic progressive lymphoedema (CPL) in horses, a disease of certain draught breeds, is associated with altered elastin metabolism. The characteristic lesions are seen in the skin of the lower (distal) limbs. This study was based on horses of susceptible breeds, with and without CPL, and on horses of a non-susceptible breed. Skin samples were obtained for examination from the neck (considered a non-affected region) and from the distal limb. The skin lesions were characterized histologically and the dermal elastic fibres were evaluated morphologically and quantitatively. In all horses the mean...

Antibodies to elastin peptides in sera of Belgian Draught horses with chronic progressive lymphoedema.

Equine veterinary journal October 4, 2007 Volume 39, Issue 5418-421doi: 10.2746/042516407x205888

van Brantegem L, de co*ck HE, Affolter VK, Duchateau L, Hoogewijs MK, Govaere J, Ferraro GL, Ducatelle R.Chronic progressive lymphoedema (CPL) is a recently recognised disease of the lymphatic system characterised by lesions in the skin of the lower legs in several draught horse breeds, including the Belgian Draught hourse. Clinical signs slowly progress and result in severe disfigurement of the limbs. Ideally, supportive treatment should be started early in the disease process. However early diagnosis and monitoring progression of CPL is still a challenge. Objective: Elastin changes, characterised by morphological alterations as well as increased desmosine levels, in the skin of the distal limbs...

Evaluation of FOXC2 as a candidate gene for chronic progressive lymphedema in draft horses.

Young AE, Bower LP, Affolter VK, De co*ck HE, Ferraro GL, Bannasch DL.Chronic progressive lymphedema (CPL) is a debilitating condition identified in Clydesdales, Shires and Belgian draft horses and results in progressive swelling of the lower legs associated with the development of thick skin folds, ulcerations, fibrosis and marked hyperkeratosis. The result is severe discomfort and recurrent secondary infection, often requiring euthanasia. Due to the delayed onset, many horses are bred prior to diagnosis. CPL has only been documented in three related draft horse breeds, suggesting a genetic cause. Determining the molecular basis would enable owners to test hors...

Measurement of skin desmosine as an indicator of altered cutaneous elastin in draft horses with chronic progressive lymphedema.

De co*ck HE, Affolter VK, Farver TB, Van Brantegem L, Scheuch B, Ferraro GL.Chronic progressive lymphedema in Clydesdale and Shire draft horses causes severe disability of the limbs which leads to premature death of these horses. Since appropriate function of lymph vessels is dependent on the presence of viable elastin fibers, the goal of this study was to document differences in skin elastin fibers in affected horse breeds, compared to a nonaffected draft horse breed. Results: Biochemical analysis of cutaneous desmosine, a cross-linking amino acid found only in elastin, was used to measure elastin in the skin from 110 draft horses. This included 7 normal, 38 mildly a...